Elucidating the dynamics of polymer transport through nanopores using asymmetric salt concentrations

While notable progress has been made in recent years both experimentally and theoretically understanding the highly complex dynamics of polymer capture transport through nanopores, there remains significant disagreement between experimental observation theoretical prediction that needs to be resolved. Asymmetric salt concentrations, where concentrations ions on each side membrane are different, can used enhance rates prolong translocation times electrophoretically driven polymers translocating a nanopore from low concentration reservoir, which attractive features for single-molecule analysis. However, since asymmetric affect electrophoretic pull inside outside pore differently, it also offers useful control parameter elucidate otherwise inseparable physics process. In this work, we attempt paint complete picture symmetric conditions by reporting dependence multiple metrics voltage, length, gradient. Using conditions, observe predictions tension propagation theory, infer impact electric field capturing altering conformations prior translocation.